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KMID : 0854720110310040304
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Korean Journal of Asthma, Allergy and Clinical Immunology
2011 Volume.31 No. 4 p.304 ~ p.306
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A Case of Acute Generalized Exanthematous Pustulosis Induced by Sodium Salicylate
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Yu Mi
Han Tae-Young
Lee Hyun-Kyung
Son Sook-Ja
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Abstract
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Background:Acute generalized exanthematous pustulosis (AGEP) is a rare disease mostly related to drug eruption. The skin lesions present as widespread sterile pustules on erythematous bases, usually accompanied by fever and leukocytosis.
Case History:A 62 year old woman presented with generalizedmultiple tiny pustules and erythematous confluent
patches on the trunk and proximal extremities. Two weeks ago, a sodium salicylate agent was injected at a local clinic
to subside chilling sensation. The skin lesion appeared 10 days after the injection and was accompanied by a high
fever.
Results:Laboratory tests revealed leukocytosis and elevated erythrocyte sedimentation rate. The histopathological examination of the skin biopsy specimen showed subcorneal spongiform pustules with perivascular inflammatory cell
infiltration. The patient was diagnosed with AGEP and treated with systemic steroids and antihistamines. The lesion resolved after 3 weeks.
Conslusion:Herein, we report a rare case of AGEP induced by sodium salicylate injection.
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KEYWORD
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Acute generalized exanthematous pustulosis, Drug eruptions, Sodium salicylate
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